If you've upgraded from an earlier version of EditPad Pro or you've switched to EditPad from a competing text editor, you may find that some of the Alt+Letter key combinations to access menu items no longer work or trigger a different command.
EditPad Pro 6 and later allow you to assign two-key shortcuts to any command or menu item. E.g. if you can't get over the fact that Alt+E, F no longer opens the search panel, you could assign this key combination to the Search|Prepare to Search menu item, instead of the default Ctrl+F.
To do so, open the Options menu, click on the Preferences item, and switch to the Keyboard tab. Click on the Prepare to Search item in the list with available commands. Turn on the "two-key shortcut" radio button. Click on the "shortcut key" box and press Alt+E. Click on the "2nd key" box and press F. Click OK and from now on Alt+E, F will open the search panel.
Note that any Alt+letter shortcuts you assign take precedence over the menu items. If you assign Alt+E, F as described above, you can no longer use Alt+E to open the Edit menu. To access the Edit menu, you'll need to press Alt, release Alt, and then press E. Incidentally, this method of accessing the menu works in any Windows application that uses a standard menu bar.
EditPad Pro's two-key shortcuts feature also makes it possible for EditPad Pro to emulate the traditional two-key shortcuts used by the venerable WordStar word processor. In Options|Preferences|Keyboard, click on the "apply WordStar shortcut keys" button and turn on the "use WordStar navigation keys" checkbox.